On May 27, 1862 -- back when San Diego had about 750 people -- the largest earthquake in the city's recorded struck about noon, producing shaking felt as far away as Los Angeles. The 5.9 quake appears to have started on a fault in the North Island area.

A California man has pleaded guilty to federal charges that he was part of a betting ring involving the University of San Diego's basketball team.

The Chicago Cubs need offense. Their top prospect, first baseman Anthony Rizzo, has a .351 batting average with 16 home runs and a .415 on-base percentage (OBP) in 174 at-bats for the Triple-A Iowa Cubs in 2012. Rizzo has a 1.116 on-base plus slugging percentage (OPS). He also hit 26 homers with a 1.056 OPS with the San Diego Padres' Triple-A affiliate in 2011.

The San Diego City Council is supposed to review contracts given to nonprofit agencies or government departments above $500,000 and that threshold may be too easily breached by issuing multiple smaller contracts or extending work year by year, a new audit report says.

( University of California - San Diego ) Five scientists from the University of California, San Diego and its School of Medicine have been awarded almost $12 million in new grants from the California Institute for Regenerative Medicine to conduct stem cell-based research into regenerating spinal cord injuries, repairing gene mutations that cause amyotrophic lateral sclerosis and finding new ...

SAN DIEGO -- Apricus Biosciences, Inc. ("Apricus Bio" or the "Company") (http://www.apricusbio.com) announced today that the Canadian Intellectual Property Office issued a Notice of ...

For the past year, Freedom Station has been a place where San Diego sailors and Marines with broken bodies start their journey to a new life.

The campaign for San Diego mayor at the moment has come down to a race for the second spot in the November runoff, and it seems the other major candidates are trying their best to keep Assemblyman Nathan Fletcher from getting it.

SAN DIEGO (AP) A California man has pleaded guilty to federal charges that he was part of a betting ring involving the University of San Diego's basketball team.

SAN DIEGO (AP) -- A California man has pleaded guilty to federal charges that he was part of a betting ring involving the University of San Diego's basketball team.